Blar i forfatter "Platten, Michael"

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    • Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production 

      Mohapatra, Soumya R; Sadik, Ahmed; Sharma, Suraj; Poschet, Gernot; Gegner, Hagen M; Lanz, Tobias V; Lucarelli, Philippe; Klingmüller, Ursula; Platten, Michael; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-19)
      The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic ...

    • Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma 

      Sharma, Suraj; Heiland, Ines; Panitz, Verena; Koncarevic, Sasa; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Jürgenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflüger, Irada; Wick, Antje; Pfänder, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von deimling, Andreas; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a better understanding of Trp metabolism is required.<p> <P>Methods: The combination of LC-MS/MS with chemical isobaric labeling enabled the simultaneous quantitative ...

    • Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation 

      Adam, Isabell; Dewi, Dyah L.; Mooiweer, Joram; Sadik, Ahmed; Mohapatra, Soumya R.; Berdel, Bianca; Keil, Melanie; Sonner, Jana K.; Thedieck, Kathrin; Rose, Adam J.; Platten, Michael; Heiland, Ines; Trump, Saskia; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-05)
      Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is incorporated into proteins after it is attached to its tRNA by tryptophanyl-tRNA synthestases. As ...